Research Diets官网代理商 动物饲料代理商

特色

Research Diets官网代理商 动物饲料代理商

美国research diets公司是一家专业生产实验室动物饲料的大型公司,包括脂肪热能的颗粒饲料及各种维生素缺乏饲料的专业供应商,Research Diets是生产动物实验用高脂肪饲料的先驱,可配制高达 60 kcal% 的高脂肪饲料,成份內含各式脂肪及碳水化合物,Research Diets长期陪伴实验室科研人员,以配制研究需要的饲料配方,可用于诱发肥胖病及糖尿病的特殊饲料如D12450B、D12451及 D12492, Research Diets拥有配方饲料种类超过15000种,常规高端饲料10多种如AIN-76A Western饲料等
食源性肥胖症饲料    

Research Diets动物造模饲料Research diets 食源性肥胖症饲料

肥胖是一种世界范围内的慢性疾病,是导致高血压、糖尿病、冠心病、心肌梗死等多种慢性病发生的主要危险因。

 

遗传和环境因素对肥胖症的发生起重要作用,膳食则是影响肥胖症的主要的环境因素之一。膳食诱导的肥胖动物模型普遍被用于肥胖发生机理和治疗方法的研究。

 

我们与世界顶级动物饲料供应商美国RDI合作,为客户提供配方可报告、可复制、可修改的纯化饲料,我们的饲料具有造模时间短、造模效果好、有效易复制等特点。

 

重点推荐饲料:D12492和D12451。

 推荐产品  货号  规格  生产厂商
60%Kcal High-Fat(DIO) Diets D12492 12.5kg 美国RDI
45%Kcal High-Fat(DIO) Diets D12451 12.5kg 美国RDI
10%Kcal High-Fat(DIO) 7% Sucrose Control Diets match D12492 D12450J 12.5kg 美国RDI
10%Kcal High-Fat(DIO) 17% Sucrose Control Diets match D12451 D12450H 12.5kg 美国RDI
10%Kcal High-Fat(DIO) 35% Sucrose Control Diets D12450B 12.5kg 美国RDI
10%Kcal High-Fat(DIO) No Sucrose Control Diets D12450K 12.5kg 美国RDI

BD DIFCO 灭活结核杆菌(M.Tuberculosis H37 Ra) 231141 上海代理商现货

特色

BD DIFCO 灭活结核杆菌(M.Tuberculosis H37 Ra) 231141 上海代理商现货

BD DIFCO灭活结核杆菌 231141 H37 RA 冻干粉

灭活结核杆菌(冻干粉) 结核杆菌 231141 BD DIFCO灭活结核杆菌231141

BD DIFCO 灭活结核杆菌(M.Tuberculosis H37 Ra) 231141
产品名称: BD DIFCO灭活结核杆菌 231141

英文名称: M Tuberculosis H37 Ra, Desiccatedr

产品货号: 231141

产品规格: 6*100MG

产品产地: 美国

产品商标: BD DIFCO

价    格: 询价

保存与运输: 2-8 摄氏度

产品名称: BD DIFCO灭活结核杆菌231141

英文名称: M Tuberculosis H37 Ra, Desiccatedr

产品货号: 231141

产品规格: 6*100MG

产品产地: 美国

产品商标: BD DIFCO

价    格: 询价

保存与运输: 2-8 摄氏度

Wako和光纯药  Charcoal 活性炭

Wako和光纯药  Charcoal 活性炭

品牌 产品编号 产品名称 等级 规格 CAS No.
Wako  和光纯药 034-02125 Charcoal, Activated, Granular 活性炭,粒状 Wako Special Grade 100 g 7440-44-0
Wako  和光纯药 034-09325 Charcoal, Activated, pretreated, 1.18 – 2.36mm (8 – 14mesh) for Oxidant Automated Analyzer 500 ml 7440-44-0
Wako  和光纯药 034-18051 Charcoal, Activated, Broken, 0.2 – 1mm for Column Chromatography 100 g 7440-44-0
Wako  和光纯药 034-18073 Charcoal, Activated, Rod for Column Chromatography 1 kg 7440-44-0
Wako  和光纯药 030-02127 Charcoal, Activated, Granular  活性炭,粒状 Wako Special Grade 10 kg 7440-44-0
Wako  和光纯药 035-18101 Charcoal, Activated, Powder, Neutral for Column Chromatography 100 g 7440-44-0
Wako  和光纯药 030-18053 Charcoal, Activated, Broken, 0.2 – 1mm 活性炭,0.2~1mm for Column Chromatography 1 kg 7440-44-0
Wako  和光纯药 031-02135 Charcoal, Activated 活性炭 for Chromatography 500 g 7440-44-0
Wako  和光纯药 031-18061 Charcoal, Activated, Broken, 2 – 5mm 活性炭,2~5mm for Column Chromatography 100 g 7440-44-0
Wako  和光纯药 031-18083 Charcoal, Activated, Powder, Acid Washed 活性炭,粉末,酸洗的 for Column Chromatography 1 kg 7440-44-0
Wako  和光纯药 031-18103 Charcoal, Activated, Powder, Neutral 活性炭,粉末,中性 for Column Chromatography 1 kg 7440-44-0
Wako  和光纯药 037-02115 Charcoal, Activated, Powder 活性炭,粉状 Wako Special Grade 500 g 7440-44-0
Wako  和光纯药 037-02137 Charcoal, Activated for Chromatography 10 kg 7440-44-0
Wako  和光纯药 032-09321 Charcoal, Activated, pretreated, 1.18 – 2.36mm (8 – 14mesh) 活性炭,前处理剂,1.18~236mm(8~14目) for Oxidant Automated Analyzer 300 ml 7440-44-0
Wako  和光纯药 037-18063 Charcoal, Activated, Broken, 2 – 5mm for Column Chromatography 1 kg 7440-44-0
Wako  和光纯药 032-18091 Charcoal, Activated, Powder, Basic  活性炭,粉末,碱性 for Column Chromatography 100 g 7440-44-0
Wako  和光纯药 033-02117 Charcoal, Activated, Powder 活性炭,粉末 Wako Special Grade 10 kg 7440-44-0
Wako  和光纯药 038-18071 Charcoal, Activated, Rod for Column Chromatography 100 g 7440-44-0
Wako  和光纯药 038-18093 Charcoal, Activated, Powder, Basic for Column Chromatography 1 kg 7440-44-0
Wako  和光纯药 038-02145 Charcoal, Bone 骨炭 No grade 500 g 7440-44-0

上海金畔生物科技有限公司(www.jinpanbio.com)提供生命科学研究领域系列产品,包括生化试剂、诊断试剂、色谱标准品和实验仪器耗材。主营Lumiprobe Cy系列活性荧光染料;修饰性PEG(Laysan bio、NANOCS、Avanti等进口品牌PEG以及定制合成修饰性聚乙二醇、单分散小分量PEG);Sigma、Amresco、TCI、MP bio生化试剂;WAKO日本和光纯药、日本关东化学Kanto试剂、日本三菱、日本柴田科学SIBATA;Megazyme食品分析检测试剂盒、日本共立理化学;Research diets、Harlan饲料、Bio-Serv、日本CLEA Japan品牌的动物饲料;Oxoid、Nissui日水、日本荣研、BD difco、Himedia品牌微生物培养基;免疫诊断试剂包括:Bethyl抗体;Biolegend流式抗体、Abcam、CST、Santa Cruz抗体;Roche、TOYOBO、NEB品牌的酶;中检所、TRC、药典USP、EP、Reagecon标准品;耗材和仪器包括Whatman、日本Advantec滤膜、Millipore品牌的各种滤膜、滤器和柱子填料等、Hampton蛋白结晶试剂耗材、老鼠软管灌胃针、动物毛发记号笔、Labnet、Wheaton瓶子、Bio-Rad伯乐、康宁Corning、Axygen、Falcon 、Eppendorf、Nunc、Nalgene、Nest品牌的培养皿、培养板、离心机、离心管、移液枪及枪头等实验室常用仪器耗材。
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服务热线:18301939375   QQ:3258089810    3259632176
Email:  info@jinpanbio.com
官网:http://www.jinpanbio.com

日本柴田科学仪器 “DPD法” 余氯测定仪

“DPD法” 余氯测定仪

“DPD法” 余氯测定仪

可从0.05开始比较,因此容易看清是否超过0.1!

根据自来水水质检测方法的妥当性评估方针,已完成对本公司DPD法粉状试剂的妥当性确认!
本方针于2012年9月6日由日本厚生劳动省公布(健水发0906第1号)。
其目的在于确认各检查机关常用的检查方法是否妥当。
本公司独自对余氯测定仪DPD法粉状试剂进行了验证,再次确认其满足评估基准。

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公司信息

柴田科学株式会社柴田科学株式会社

产品、服务特点

“DPD法” 余氯测定仪

● DPD法粉状试剂的妥当性已经过评估确认!
注:由本公司独自验证
● 加入碘化钾(另售)还可测定结合性余氯
● DPD法粉状试剂的有效期为自生产日期
起两年。该有效期年月印于包装上!

用途/应用实际事例

● 可拆卸及更换比色板!
● 可从0.05开始比较,因此容易看清是否超过0.1!

目录

DPD法 余氯测定仪

DPD法 余氯测定仪[573KB]

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Hichrom官网 Hichrom色谱柱

Hichrom品牌简介 whatman色谱柱原厂

Hichrom官网 Hichrom色谱柱

英国沃特曼一级代理 whatman总代理 玻璃微纤维滤纸

Hichrom品牌简介 whatman色谱柱原厂

Hichrom色谱柱 中国官方代理 whatman替代
固话总机:021-50837765

订货热线:15221999938

qq号:2743691513 1042640511

微信号:jinpanbio

网 址: www.jinpanbio.com
金畔博客:www.jinpanbio.cn
Email:sales@jinpanbio.com
品牌所有商:
品牌国别: 英国
代表产品: 色谱柱
品牌简介: Hichrom 英国 Hichrom www.hichrom.co.uk 英国顶级色谱柱制造商HICHROM公司制造.HICHROM公司通过ISO9002,ISO14000两大国际标准认证,每年在全世界50多个国家销售50000多根. Hichrom manufacture HPLC columns. Hichrom manufactured HPLC columns are supplied to laboratories in over 50 countries through our world-wide network of distributors. Missio

上海金畔生物科技有限公司,是英国沃特曼(Whatman)在中国最大的授权一级代理商,也是最早代理Whatman全系列产品的授权一级代理商。本公司还经销进口试剂、国产名优试剂、实验室设备、各种实验室耗材等。我公司将以优质的产品,一流的服务,与新老客户共同发展,共创繁荣的明天。以下为公司部分经销产品: 玻璃微纤维滤纸,纤维素层析填料,针头式过滤器,阳离子交换,一次性过滤器,无菌滤器,一次性无菌过滤器,进口滤纸,硬化低灰滤纸,硬化无灰滤纸,玻璃纤维滤膜,定性滤纸,定量滤纸,有黏合剂的玻璃微纤维滤纸,无黏合剂的玻璃微纤维滤纸,石英滤纸,石英滤膜,空气采样滤纸,聚碳酸酯膜等。

Whatman给实验者提供了多种材质的滤膜,先进的技术规模使得今天很多的使用者都更愿意选择Whatman产品。滤膜的孔径精确、韧性好,保证了再现性和一致性。
Whatman滤膜的孔径范围很广,从0.015到12微米,并有很多可选择的膜过滤容器。无菌和消毒包装(http://www.chemdrug.com/sell/99/)可用于特殊应用中,也有着色和网格类型可供选择。

产品编号 规格及描述 规格及描述(中文) 2010年报价 促销价

1 1820-915 GF/A Glass Sheets, 460 x 570mm 25/pk GF/A玻璃微纤维滤纸方形460x570mm 25片/盒 2450 1715

2 1001-824 Grade 1 Sheets, 75 x 100mm 500/pk 1号滤纸方型75x100mm 500片/盒 559 360

3 1960-054 Membrane Holder, Stainless Steel Support, 47mm, 300ml volume 1/pk 膜过滤器, 不锈钢支撑, 47mm, 300ml容积 1个/盒 3294 2100

4 1980-002 Membrane Holder, Stainless Steel Syringe Filter Type, 25mm 1/pk 膜过滤器, 不锈钢针头式滤器 , 25mm 1个/盒 2500 1600

5 4025-050 Cell Debris Remover 500g 细胞碎片清除剂 500g 1307 850

6 4055-005 DE32 50g 分装 DE32 纤维素离子交换剂 50g 750 720

7 4055-010 DE32 100g 分装 DE32 纤维素离子交换剂 100g 1450 1400

8 4410-221 TLC Plate, Flexible PE, Silica Gel, 20x20cm 25/pk TLC板,柔性PE,硅胶,20x20cm 25个/盒 1795 1100

9 4641-0005 Guard Cartridge SAX 5/pk 保护柱 SAX 5个/盒 1594 1000

10 4681-0502 Partisil 5 ODS-3 4.6x125mm 1/pk Partisil 5 ODS-3 4.6x125mm 1个/盒 5253 3400

11 4681-0505 Partisil 5 SAX 4.6x125mm 1/pk Partisil 5 SAX 4.6x125mm 1个/盒 5253 3400

12 7002-0425 *Membrane Circles, Polypropylene, 0.4μm 25mm 100/pk 聚丙烯膜,0.45,25MM 100片/盒 744 400

13 6701-7510 Polycap TF 75, 1μm

1/pk 囊式滤器Polycap TF 75,1μm 1个/盒 1203 780

14 6784-1350 Puradisc 13 Syringe Filter, 5.0μm PTFE 100/pk Puradisc13针头滤器5.0μmPTFE 100个/盒 1732 1100

15 6870-1304 GD/X 13 Syringe Filter, 0.45μm Nylon 150/pk GD/X 13mm多层针头式滤器, 0.45μm Nylon 150个/盒 2915 1900

16 2713T Polycap HD 75, 5.0/10.0μm, Inlet: 0.125 inch FNPT, Outlet: 0.125 inch FNPT 5/pk 囊式滤器HD75,5.0/10.0μmin/out0.125 英寸FNPT 5个/盒 3644 550/个;2500/盒

17 10401612 ME25 Membrane Circles, Mixed esters, 0.45μm, 47mm 100/pk ME25 混酯纤维素膜 圆型, 0.45μm, 47mm 100片/盒 1292 710

18 10402493 BA83 PROT 6.3X22.8CM 10PK(HS NC膜.2μm BA83 6.3×22.8cm 10片/盒 1487.9 890

19 1960-513 Membrane Hardware, 3 port stainless steel manifold 1/pk 膜过滤器, 3头不锈钢底座 1套/盒 18637 9800

英国沃特曼一级代理 whatman总代理 玻璃微纤维滤纸
上海金畔生物科技有限公司(http://www.chemdrug.com/company/)代理(http://www.chemdrug.com/invest/)whatman全线产品
英国沃特曼一级代理 whatman总代理 玻璃微纤维滤纸(http://www.chemdrug.com/invest/)英国沃特曼一级代理 whatman总代理 玻璃微纤维滤纸
固话总机:021-50837765

订货热线:15221999938

qq号:2743691513 1042640511

微信号:jinpanbio

网 址: www.jinpanbio.com
金畔博客:www.jinpanbio.cn
Email:sales@jinpanbio.com

32α-L-阿糖呋喃-木二糖(A3X) 32-α-L-Arabinofuranosyl-xylobiose (A3X) 货号:O-A3X Megazyme中文站

32α-L-阿糖呋喃-木二糖(A3X)

英文名:32-α-L-Arabinofuranosyl-xylobiose (A3X)

货号:O-A3X

规格:10 mg

CAS: 144938-89-6
Molecular Formula: C15H26O13
Molecular Weight: 414.4
Purity: > 95%

High purity 32-α-L-Arabinofuranosyl-xylobiose for or use in research, biochemical enzyme assays and in vitro diagnostic analysis. It can be used as an analytical standard or as a substrate to help characterise the activities of arabinoxylan degrading enzymes including endo-xylanase, β-xylosidase and α-L-arabinofuranosidase. This compound was prepared by the controlled enzymatic hydrolysis of wheat arabinoxylan. 

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Beta葡[萄]糖苷酶[农杆菌] Beta-Glucosidase – 600U. 货号:E-BGOSAG Megazyme中文站

Beta葡[萄]糖苷酶[农杆菌]

英文名:Beta-Glucosidase – 600U.

货号:E-BGOSAG

规格:600u

High purity beta-Glucosidase (Agrobacterium sp.) for use in research, biochemical enzyme assays and in vitro diagnostic analysis.

EC 3.2.1.21 
CAZy Family: GH1

From Agrobacterium sp. 
In 3.2 M ammonium sulphate. Stabilised with BSA. Electrophoretically homogeneous (before BSA addition).

Specific activity: 211 U/mg (40oC, pH 4.0, p-nitrophenyl β-glucoside).

Stable at 4oC for > 4 years.

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harlan teklad动物饲料官网 TD.88137 饮食诱导肥胖(DIO) Adjusted calories diet (42% from fat)

饮食诱导肥胖Envigo

harlan teklad动物饲料官网 TD.88137 饮食诱导肥胖(DIO) Adjusted calories diet (42% from fat)

用于诱导肥胖和肥胖相关并发症(如糖尿病和代谢综合征)的纯化高脂饮食通常有40-60%的能量来源于脂肪。下面的饮食表总结了一些特克拉德定制研究饮食的相关饮食特征,这些研究饮食通常用于啮齿类动物模型。

泰克乐还为其他物种,包括猪、灵长类动物和狗创造高脂肪饮食。联系我们讨论使用这些饮食或更好地满足您的需要。

通常使用的饮食诱导肥胖(DIO)技术啮齿动物饮食中含有55-60%的热量来自脂肪。
饮食特征 TD.06414 备好 TD.93075 面团 TD.07011 球团
千卡/克 5.1 4.8
脂肪,%千卡 60 55
脂肪来源,
按重量计百分比
31%猪油
3%豆油
27.4%蔬菜酥油
1.6%玉米油
脂肪酸谱,
总脂肪百分比
37%饱和
47%单不饱和
16%多不饱和
28%饱和,30%反式
28%单不饱和(顺式)
14%多不饱和
蔗糖
按重量计百分比
12.1 9.6
注记 60F10S海报数据
与D 12492比较
反式脂肪
示例修改 TD.08500椰子油
TD.09766乳脂
成分匹配,
低脂控制饮食*
TD.06416(35%蔗糖)
TD.08806(11%蔗糖)
TD.93074(21%蔗糖)
TD.120651(7%蔗糖)
参考文献
大鼠

大鼠

*控制饮食可以通过几种方式来设计,这取决于研究人员相对于高脂肪饮食想要改变什么特征。这些只是几个例子。

通常使用的饮食诱导肥胖(DIO)技术啮齿动物饮食中含有40-45%的热量来自脂肪。
饮食特征 TD.06415 TD.08811 TD.88137 备好 TD.95217
千卡/克 4.6 4.7 4.5 4.3
脂肪,%千卡 45 45 42 40
脂肪来源,
按重量计百分比
19.5%猪油
3%豆油
21%乳脂
2%豆油
21%乳脂 10.6%蔬菜酥油
4%乳脂
4%豆油
脂肪酸谱,
总脂肪百分比
36%饱和
46%单不饱和
18%多不饱和
61%饱和
31%单不饱和
8%多不饱和
62%饱和
27%单不饱和
5%多不饱和
34%饱和,18%反式
29%单不饱和(顺式)
19%多不饱和
蔗糖
按重量计百分比
22.8 36.8 34.5 15.8
注记 与D 12451比较 45F30S海报数据 “西餐”
添加胆固醇
反式脂肪
示例修改 TD.110716乳脂
TD.10670无染料
TD.130784猪油
TD.120438无染料
TD.07201猪油
TD.00573椰子油,不含胆固醇
TD.09682蓝色染料
TD.07734绿色染料
成分匹配,
低脂控制饮食*
TD.06416(35%蔗糖)
TD.110675(18%蔗糖)
TD.120455(6%蔗糖,抗性淀粉)
TD.120724(14%蔗糖)
TD.05230(34%蔗糖)
TD.08485(12%蔗糖)
TD.06101(6%蔗糖)
参考文献
大鼠

大鼠

大鼠

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从脂肪中摄取55-60%卡路里的食物TD.06414TD.93075通常用于诱发啮齿动物肥胖。虽然与典型的人类脂肪摄入相比,这些饮食被认为是极端的,但在大多数啮齿类动物中,这些饮食能有效地启动快速增重。由于脂肪含量较高,碳水化合物的摄入空间较小,因此碳水化合物(特别是蔗糖)含量相对较低。如果你对高脂肪和高碳水化合物感兴趣,那就看看脂肪中含有40-45%卡路里的饮食(通常被称为西方饮食)。

随着脂肪水平的增加,球团的质量(耐久性)经常受到损害。一些高脂肪配方只有在非颗粒形式,或需要特定的碳水化合物,麦芽糊精,用于球团。根据使用的脂肪和碳水化合物来源,非颗粒形式可能是致密和碎屑,面团样,或糊状。虽然使用非颗粒饮食更具有挑战性,但许多研究人员仍在使用非颗粒饮食来建立饮食诱导的肥胖模型,因为这些研究人员怀疑,较软的饮食形式可能会促进肥胖的发展。

从脂肪中摄取40-45%卡路里的饮食,如TD.95217TD.88137TD.06415,和TD.08811,代表了另一种流行的饮食模式-诱发肥胖的工作。这些食物的蔗糖含量是高脂肪饮食的两倍或三倍。高水平的简单碳水化合物,如蔗糖和果糖,可能有助于促进高甘油三酯血症,胰岛素抵抗和脂肪肝。高蔗糖、高饱和或反式脂肪的饮食在肥胖和心血管领域常被称为“西方饮食”。一些“西方饮食”有进一步的修改脂肪酸剖面,甚至特定的维生素和矿物质调整,以更紧密地匹配西方饮食模式。有关特定脂肪酸的修改,请参阅脂肪/脂肪调节饮食一页。

许多用于诱导啮齿动物肥胖的饮食可以用于增强糖尿病相关表型,如胰岛素抵抗和葡萄糖不耐受。然而,空腹高血糖特征的糖尿病(葡萄糖>200 mg/dL)是罕见的饮食方法。预先喂食高脂饮食,诱导一定程度的肥胖和胰岛素抵抗,然后给予小剂量链脲佐菌素(STZ)可能是一个有效的方法,如果公开高血糖是需要。

除了不同类型的碳水化合物外,还有许多不同水平和类型的脂肪,从蔗糖(高精制,简单消化)到玉米淀粉(精制,但更复杂),再到抗性淀粉(精制,但不能完全消化)。一个非常基本的净化控制饮食将是AIN-93M (TD.94048) 或AIN-93g(TD.94045)AIN-93日粮中蔗糖含量在10%左右,脂肪来源于具有健康脂肪酸的大豆油。更多的控制特定DIO饮食的例子可以在上表中找到。

许多研究人员选择将高脂肪喂养的动物与食用天然成分谷物的动物(也称为标准饮食或周食)进行比较。这些饮食在营养来源和水平以及非营养因素(如植酸盐或植物雌激素)存在的情况下存在差异。根据您的主要比较,它可能适合作为您的对照/参考组谷物基础的饮食。然而,这样的比较限制了对饮食模式和特定饮食成分的推断。

Diet induced obesity | Envigo

Purified high fat diets used to induce obesity and obesity-related complications such as diabetes and metabolic syndrome typically have 40-60% of energy derived from fat. The diet tables below summarize relevant diet features for several Teklad custom research diets commonly used in rodent models.

Teklad also creates high-fat diets for other species, including pigs, primates, and dogs. Contact us to discuss the use of these diets or one that better meets your needs.

Commonly-used diet-induced obesity (DIO) Teklad rodent diets with 55-60% of calories from fat
Diet features TD.06414stocked TD.93075dough TD.07011pellet
Kcal/g 5.1 4.8
Fat, % Kcal 60 55
Fat Sources,
% by weight
31% lard
3% soybean oil
27.4% vegetable shortening
1.6% corn oil
Fatty acid profile,
% total fat
37% saturated
47% monounsaturated
16% polyunsaturated
28% saturated, 30% trans
28% monounsaturated (cis)
14% polyunsaturated (cis)
Sucrose,
% by weight
12.1 9.6
Notes 60F10S poster data
Compare to D12492
Trans fat
Example modifications TD.08500coconut oil
TD.09766 milk fat
Ingredient matched,
low fat control diets*
TD.06416 (35% sucrose)
TD.08806 (11% sucrose)
TD.93074 (21% sucrose)
TD.120651 (7% sucrose)
References Mouse
Rat
Mouse
Rat

*Control diets can be designed in several ways, depending on what features the researcher wants to modify relative to the high-fat diet. These are just a few examples.

Commonly-used diet-induced obesity (DIO) Teklad rodent diets with 40-45% of calories from fat
Diet features TD.06415 TD.08811 TD.88137stocked TD.95217
Kcal/g 4.6 4.7 4.5 4.3
Fat, % Kcal 45 45 42 40
Fat sources,
% by weight
19.5% lard
3% soybean oil
21% milk fat
2% soybean oil
21% milk fat 10.6% vegetable shortening
4% milk fat
4% soybean oil
Fatty acid profile,
% total fat
36% saturated
46% monounsaturated
18% polyunsaturated
61% saturated
31% monounsaturated
8% polyunsaturated
62% saturated
27% monounsaturated
5% polyunsaturated
34% saturated, 18% trans
29% monounsaturated (cis)
19% polyunsaturated (cis)
Sucrose,
% by weight
22.8 36.8 34.5 15.8
Notes Compare to D12451 45F30S poster data “Western Diet”
Cholesterol added
Trans fat
Example modifications TD.110716 milk fat
TD.10670 no dye
TD.130784 lard
TD.120438 no dye
TD.07201 lard
TD.00573 h-coconut oil, no cholesterol
TD.09682 blue dye
TD.07734 green dye
Ingredient matched,
low fat control diets*
TD.06416 (35% sucrose)
TD.110675 (18% sucrose)
TD.120455 (6% sucrose, resistant starch)
TD.120724 (14% sucrose)
TD.05230 (34% sucrose)
TD.08485 (12% sucrose)
TD.06101 (6% sucrose)
References Mouse
Rat
Mouse
Rat
Mouse
Rat
Mouse
Rat
Collapse All Tabs

Diets with 55-60% of calories from fat like TD.06414 and TD.93075 are commonly used for inducing obesity in rodents. While considered extreme compared to typical human fat consumption, these diets are effective in initiating rapid weight gain in most rodents. With higher fat content there is less room for carbohydrate, thus the carbohydrate (particularly sucrose) amount is relatively low compared to other obesity inducing diets. If you are interested in high fat and high carbohydrate, look at diets with 40-45% of calories from fat (often referred to as western diets).

As the fat level increases, pellet quality (durability) is often compromised. Some higher fat formulas are available only in non-pelleted form or require specific carbohydrate, maltodextrin, for pelleting. Depending on the fat and carbohydrate sources used, the non-pelleted form could be dense and crumbly, dough-like, or paste-like. Though a little more challenging to work with, non-pelleted diet is still used by many researchers for diet-induced obesity models as these researchers suspect the softer form may enhance obesity development.

Diets with 40-45% of calories from fat, like TD.95217TD.88137TD.06415, and TD.08811, represent another popular diet pattern for diet-induced obesity work. These diets have double or triple the amount of sucrose found in higher fat diets. High levels of simple carbohydrate like sucrose and fructose may help to promote hypertriglyceridemia, insulin resistance, and fatty liver. Diets with a pattern of high sucrose and high saturated or trans fat are often referred to as “Western Diets” in obesity and cardiovascular fields. Some “Western Diets” have further modifications to the fatty acid profile or even specific vitamin and minerals adjustments to be even more closely matched to a Western Diet pattern. For specific fatty acid modifications, see examples on our fat/lipid adjusted diets page.

Many of the same diets used for inducing obesity in rodents can be used to enhance diabetes related phenotypes like insulin resistance and glucose intolerance. However, fasting hyperglycemia characteristic of diabetes (glucose > 200 mg/dL) is uncommon with a diet only approach. Pre-feeding a high fat diet to induce a certain level of obesity and insulin resistance and then giving low-dose streptozotocin (STZ) may be an effective approach if overt hyperglycemia is desired.

There are many options with different levels and types of fat in addition to different types of carbohydrate ranging from sucrose (highly refined, simple digestion) to corn starch (refined, but more complex) to resistant starch (refined, but not fully digestible). A very basic purified control diet would be AIN-93M (TD.94048) or AIN-93G (TD.94045). AIN-93 diets have a moderate amount of sucrose at ~10%, and fat is from soybean oil with a healthy fatty acid profile. Additional examples of controls for specific DIO diets can be found in the above tables.

Many researchers choose to compare their high fat fed animals to animals fed a natural ingredient, grain-based diet (also referred to as standard diets or chow). These diets differ in the source and level of nutrients as well as in the presence of non-nutritive factors (such as phytates or phytoestrogens). Depending on what your main comparisons are, it may be suitable to have a grain-based diet as your control/reference group. However, making such comparisons limits inferences to dietary patterns versus a specific dietary component.