Each of the chemicals in GRAS Screen 1 and 2 have been used under one or more of the following categories. As (1) a Generally Recognized As Safe (GRAS) substance, (2) a pharmaceutical excipient, (3) a normal physiological constituent, (4) a metabolic byproduct, and/or (5) a Everything Added to Food in the United States (EAFUS) substance.

GRAS Screen 1 samples four low molecular weight Polyethylene glycols (300, 400, MME 550, and 600) versus twenty-four salts, encompassing pH 4-9. GRAS Screen 1 is supplied in a 96 Deep Well block format and is compatible with robotic and multi-channel pipet liquid handling systems. GRAS Screen 1 is compatible with vapor diffusion, free interface diffusion, and microbatch crystallization methods. For research use only.

GRAS Screen 2 samples four medium molecular weight Polyethylene glycols (1,000, MME 2,000, 3,350, & 4,000) versus twenty-four salts, encompassing pH 4-9. GRAS Screen 2 is supplied in a 96 Deep Well block format and is compatible with robotic and multi-channel pipet liquid handling systems. GRAS Screen 2 is compatible with vapor diffusion, free interface diffusion, and microbatch crystallization methods. For research use only.

GRAS Screen 1

GRAS Screen 2

1. Optimization of crystallization conditions for biological macromolecules. Alexander McPherson and Bob Cudney. Acta Crystallographica Section F Volume 70, Issue 11, pages 1445-1467, November 2014.

2. Crystallization of intact monoclonal antibodies. Harris LJ, Skaletsky E, McPherson A. Proteins. 1995 Oct;23(2):285-9.

3. Crystalline monoclonal antibodies for subcutaneous delivery. Yang MX1, Shenoy B, Disttler M, Patel R, McGrath M, Pechenov S, Margolin AL. Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):6934-9.

4. Fast and Scalable Purification of a Therapeutic Full-Length Antibody Based on Process Crystallization. Dariusch Hekmat et al, Biotechnology and Bioengineering, Vol. 110, No. 9, September, 2013.

5. Towards Protein Crystallization as a Process Step in Downstream Processing of Therapeutic Antibodies: Screening and Optimization at Microbatch Scale. Yuguo Zang et al, PLoS One. 2011; 6(9): e25282.

6. Crystallization as a tool for bioseparation. Bob Cudney, Am Biotechnol Lab. 1994 Jun;12(7):42.

7. Large-scale crystallization of proteins for purification and formulation. Hekmat D. Bioprocess Biosyst Eng. 2015 Jul;38(7):1209-31. doi: 10.1007/s00449-015-1374-y

8. Using X-Ray Crystallography to Simplify and Accelerate Biologics Drug Development. Brader ML, Baker EN, Dunn MF, Laue TM, Carpenter JF. J Pharm Sci. 2017 Feb;106(2):477-494. doi: 10.1016/j.xphs.2016.10.017.

9. Excipients and Their Role in Approved Injectable Products: Current Usage and Future Directions. Sandeep Nema and Ronald J. Brendell, PDA J Pharm Sci and Tech 2011, 65 287-332.

Hampton Research, first in crystallization since 1991, developing and delivering crystallization and optimization screens, reagents, plates, and other tools for the crystallization of biological macromolecules, including proteins (antibody), peptides (insulin), and nucleic acids (DNA).

• Products

|

• Gallery

|

• My Account

|

• Contact Us

|

• Quick Order
• Support

• Privacy Policy

|

• Terms and Conditions

• Products

|

• Gallery

|

• My Account

|

• Support

|

• Contact Us

|

• Quick Order

|

• Privacy Policy

|

• Terms and Conditions

© 2022 HAMPTON RESEARCH CORP.

| Website by Skyhound Internet

Synonyms: L-(+)-Tartaric acid disodium salt or Disodium tartrate dihydrate or Sodium tartrate dihydrate
C₄H₄Na₂O₆ • 2H₂O
M_r 230.08
CAS [6106-24-7]
EC Number 212-773-3
Merck 14,8684
Beilstein Registry Number 6121732
MDL Number MFCD00150035
PubChem Substance ID 24899620
Purity ≥ 99.0%

Measured pH range: 7.5 – 8.8 at 25°C
Measured Conductivity Range: 67.9 – 71.4 mS/cm at 25°C
Measured Refractive Index Range: 1.37544 – 1.37625 at 20°C

Total Impurities ≤0.005% insoluble matter passes filter test
Al  ≤0.0005%
As ≤0.00001%
Ba ≤0.0005%
Bi  ≤0.0005%
Ca ≤0.001%
Cd ≤0.0005%
Cl  ≤0.0005%
Co ≤0.0005%
Cr ≤0.0005%
Cu ≤0.0005%
Fe ≤0.0005%
K  ≤0.005%
Li  ≤0.0005%
Mg ≤0.0005%
Mn ≤0.0005%
Mo ≤0.0005%
Ni  ≤0.0005%
Pb  ≤0.0005%
PO₄ ≤0.0005%
SO₄ ≤0.005%
Sr ≤0.0005%
Zn ≤0.0005%

1.5 M Sodium tartrate dibasic dihydrate

Hampton Research, first in crystallization since 1991, developing and delivering crystallization and optimization screens, reagents, plates, and other tools for the crystallization of biological macromolecules, including proteins (antibody), peptides (insulin), and nucleic acids (DNA).

• Products

|

• Gallery

|

• My Account

|

• Contact Us

|

• Quick Order
• Support

• Privacy Policy

|

• Terms and Conditions

• Products

|

• Gallery

|

• My Account

|

• Support

|

• Contact Us

|

• Quick Order

|

• Privacy Policy

|

• Terms and Conditions

© 2022 HAMPTON RESEARCH CORP.

| Website by Skyhound Internet

Heavy Atom Screen M1 01 100mg

Heavy Atom Screen M1 100mg

Heavy Atom Screen M1 02 100mg

Heavy Atom Screen M1 100mg

Heavy Atom Screen M1 03 100mg

Heavy Atom Screen M1 04 100mg

Heavy Atom Screen M1 05 100mg

Each of the chemicals in GRAS Screen 3 and 4 have been used under one or more of the following categories. As (1) a Generally Recognized As Safe (GRAS) substance, (2) a pharmaceutical excipient, (3) a normal physiological constituent, (4) a metabolic byproduct, and/or (5) a Everything Added to Food in the United States (EAFUS) substance.

GRAS Screen 3 samples twenty four salts, encompassing pH 4-9 versus four low molecular weight Polyethylene glycols (300, 400, MME 550, & 600). GRAS Screen 3 is supplied in a 96 Deep Well block format and is compatible with robotic and multi-channel pipet liquid handling systems. GRAS Screen 3 is compatible with vapor diffusion, free interface diffusion, and microbatch crystallization methods. For research use only.

GRAS Screen 4 samples twenty four salts, encompassing pH 4-9 versus four medium molecular weight Polyethylene glycols (1,000, MME 2,000, 3,350 & 4,000). GRAS Screen 4 is supplied in a 96 Deep Well block format and is compatible with robotic and multi-channel pipet liquid handling systems. GRAS Screen 4 is compatible with vapor diffusion, free interface diffusion, and microbatch crystallization methods. For research use only.

GRAS Screen 3

GRAS Screen 4

1. Optimization of crystallization conditions for biological macromolecules. Alexander McPherson and Bob Cudney. Acta Crystallographica Section F Volume 70, Issue 11, pages 1445-1467, November 2014.

2. Crystallization of intact monoclonal antibodies. Harris LJ, Skaletsky E, McPherson A. Proteins. 1995 Oct;23(2):285-9.

3. Crystalline monoclonal antibodies for subcutaneous delivery. Yang MX1, Shenoy B, Disttler M, Patel R, McGrath M, Pechenov S, Margolin AL. Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):6934-9.

4. Fast and Scalable Purification of a Therapeutic Full-Length Antibody Based on Process Crystallization. Dariusch Hekmat et al, Biotechnology and Bioengineering, Vol. 110, No. 9, September, 2013.

5. Towards Protein Crystallization as a Process Step in Downstream Processing of Therapeutic Antibodies: Screening and Optimization at Microbatch Scale. Yuguo Zang et al, PLoS One. 2011; 6(9): e25282.

6. Crystallization as a tool for bioseparation. Bob Cudney, Am Biotechnol Lab. 1994 Jun;12(7):42.

7. Large-scale crystallization of proteins for purification and formulation. Hekmat D. Bioprocess Biosyst Eng. 2015 Jul;38(7):1209-31. doi: 10.1007/s00449-015-1374-y

8. Using X-Ray Crystallography to Simplify and Accelerate Biologics Drug Development. Brader ML, Baker EN, Dunn MF, Laue TM, Carpenter JF. J Pharm Sci. 2017 Feb;106(2):477-494. doi: 10.1016/j.xphs.2016.10.017.

9. Excipients and Their Role in Approved Injectable Products: Current Usage and Future Directions. Sandeep Nema and Ronald J. Brendell, PDA J Pharm Sci and Tech 2011, 65 287-332.

Hampton Research, first in crystallization since 1991, developing and delivering crystallization and optimization screens, reagents, plates, and other tools for the crystallization of biological macromolecules, including proteins (antibody), peptides (insulin), and nucleic acids (DNA).

• Products

|

• Gallery

|

• My Account

|

• Contact Us

|

• Quick Order
• Support

• Privacy Policy

|

• Terms and Conditions

• Products

|

• Gallery

|

• My Account

|

• Support

|

• Contact Us

|

• Quick Order

|

• Privacy Policy

|

• Terms and Conditions

© 2022 HAMPTON RESEARCH CORP.

| Website by Skyhound Internet

Synonyms: Sodium isothiocyanate or Sodium rhodanate or Sodium rhodanide or Sodium sulfocyanate
NaSCN
CNNaS
M_r 81.07
CAS Number [540-72-7]
EC Number 208-754-4
Beilstein Registry Number 3594965
MDL Number MFCD00011123
Purity ≥ 98.0%

Measured pH range: 6.8 – 9.5 at 25°C
Measured Conductivity Range: 158.6 – 170.2 mS/cm at 25°C
Measured Refractive Index Range: 1.45613 – 1.46117 at 20°C

Ca ≤0.02%
Cd ≤0.005%
Cl  ≤0.05%
Co ≤0.005%
Cu ≤0.005%
Fe ≤0.005%
K  ≤0.2%
Ni ≤0.005%
Pb ≤0.005%
SO₄ ≤0.05%
Zn ≤0.005%

8.0 M Sodium thiocyanate

1. A Toxin that recognizes muscarinic acetylcholine receptors Preparation and characterization of crystals suitable for structural analysis. Menez, R; Ducruix, A. J Mol Biol 232, 997- 998, 1993.

Hampton Research, first in crystallization since 1991, developing and delivering crystallization and optimization screens, reagents, plates, and other tools for the crystallization of biological macromolecules, including proteins (antibody), peptides (insulin), and nucleic acids (DNA).

• Products

|

• Gallery

|

• My Account

|

• Contact Us

|

• Quick Order
• Support

• Privacy Policy

|

• Terms and Conditions

• Products

|

• Gallery

|

• My Account

|

• Support

|

• Contact Us

|

• Quick Order

|

• Privacy Policy

|

• Terms and Conditions

© 2022 HAMPTON RESEARCH CORP.

| Website by Skyhound Internet

Each of the chemicals in GRAS Screen 5 and 6 has been used under one or more of the following categories. As (1) a Generally Recognized As Safe (GRAS) substance, (2) a pharmaceutical excipient, (3) a normal physiological constituent, (4) a metabolic byproduct, and/or (5) a Everything Added to Food in the United States (EAFUS) substance.

GRAS Screen 5 samples four low molecular weight Polyethylene glycols (300, 400, MME 550, and 600) at three concentrations versus eight unique buffers encompassing pH 4.5 to 10. GRAS Screen 5 is supplied in a 96 Deep Well block format and is compatible with robotic and multi-channel pipet liquid handling systems. GRAS Screen 5 is compatible with vapor diffusion, free interface diffusion, and microbatch crystallization methods. For research use only.

GRAS Screen 6 samples four medium molecular weight Polyethylene glycols (1,000, MME 2,000, 3,350, & 4,000) at three concentrations versus eight unique buffers encompassing pH 4.5 to 10. GRAS Screen 6 is supplied in a 96 Deep Well block format and is compatible with robotic and multi-channel pipet liquid handling systems. GRAS Screen 6 is compatible with vapor diffusion, free interface diffusion, and microbatch crystallization methods. For research use only.

GRAS Screen 5

GRAS Screen 6

1. Optimization of crystallization conditions for biological macromolecules. Alexander McPherson and Bob Cudney. Acta Crystallographica Section F Volume 70, Issue 11, pages 1445-1467, November 2014.

2. Crystallization of intact monoclonal antibodies. Harris LJ, Skaletsky E, McPherson A. Proteins. 1995 Oct;23(2):285-9.

3. Crystalline monoclonal antibodies for subcutaneous delivery. Yang MX1, Shenoy B, Disttler M, Patel R, McGrath M, Pechenov S, Margolin AL. Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):6934-9.

4. Fast and Scalable Purification of a Therapeutic Full-Length Antibody Based on Process Crystallization. Dariusch Hekmat et al, Biotechnology and Bioengineering, Vol. 110, No. 9, September, 2013.

5. Towards Protein Crystallization as a Process Step in Downstream Processing of Therapeutic Antibodies: Screening and Optimization at Microbatch Scale. Yuguo Zang et al, PLoS One. 2011; 6(9): e25282.

6. Crystallization as a tool for bioseparation. Bob Cudney, Am Biotechnol Lab. 1994 Jun;12(7):42.

7. Large-scale crystallization of proteins for purification and formulation. Hekmat D. Bioprocess Biosyst Eng. 2015 Jul;38(7):1209-31. doi: 10.1007/s00449-015-1374-y

8. Using X-Ray Crystallography to Simplify and Accelerate Biologics Drug Development. Brader ML, Baker EN, Dunn MF, Laue TM, Carpenter JF. J Pharm Sci. 2017 Feb;106(2):477-494. doi: 10.1016/j.xphs.2016.10.017.

9. Excipients and Their Role in Approved Injectable Products: Current Usage and Future Directions. Sandeep Nema and Ronald J. Brendell, PDA J Pharm Sci and Tech 2011, 65 287-332.

Hampton Research, first in crystallization since 1991, developing and delivering crystallization and optimization screens, reagents, plates, and other tools for the crystallization of biological macromolecules, including proteins (antibody), peptides (insulin), and nucleic acids (DNA).

• Products

|

• Gallery

|

• My Account

|

• Contact Us

|

• Quick Order
• Support

• Privacy Policy

|

• Terms and Conditions

• Products

|

• Gallery

|

• My Account

|

• Support

|

• Contact Us

|

• Quick Order

|

• Privacy Policy

|

• Terms and Conditions

© 2022 HAMPTON RESEARCH CORP.

| Website by Skyhound Internet

Synonym: Dicarboxylic acid C4 or Butanedioic acid
C₄H₆O₄
HOOCCH₂CH₂COOH
M_r 118.09
CAS Number [110-15-6]
EC Number 203-740-4
Beilstein Registry Number 1754069
RTECS WM4900000
MDL Number MFCD00002789
PubChem Substance ID 24848479
Merck 14,8869
Purity ≥ 99.5%
pKa1 = 4.2
pKa2 = 5.6

HR2-709 is titrated to pH 7.0 using NaOH
Measured Conductivity Range: 70.1 – 80.2 mS/cm at 25°C
Measured Refractive Index Range: 1.36344 – 1.36407 at 20°C

Ca ≤0.005%
Cd ≤0.0005%
Cl  ≤0.001%
Co ≤0.0005%
Cr ≤0.0005%
Cu ≤0.0005%
Fe ≤0.0005%
K   ≤0.005%
Mg ≤0.001%
Mn ≤0.0005%
N   ≤0.001%
Na ≤0.0005%
Ni  ≤0.0005%
Pb  ≤0.0005%
PO₄ ≤0.001%
SO₄ ≤0.003%
Zn ≤0.0005%

1.2 M Succinic acid pH 7.0

1. A comparison of salts for the crystallization of macromolecules. Alexander McPherson. Protein Science (2001), 10:418-422.

Hampton Research, first in crystallization since 1991, developing and delivering crystallization and optimization screens, reagents, plates, and other tools for the crystallization of biological macromolecules, including proteins (antibody), peptides (insulin), and nucleic acids (DNA).

• Products

|

• Gallery

|

• My Account

|

• Contact Us

|

• Quick Order
• Support

• Privacy Policy

|

• Terms and Conditions

• Products

|

• Gallery

|

• My Account

|

• Support

|

• Contact Us

|

• Quick Order

|

• Privacy Policy

|

• Terms and Conditions

© 2022 HAMPTON RESEARCH CORP.

| Website by Skyhound Internet